| 01/16/26 | Marantz Jing L.CHIEF MEDICAL OFFICER | Sell | 5,798 | $44.48 | $257.88K |
| 01/14/26 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 1,407 | $18.08 | $25.44K |
| 01/14/26 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 321 | $7.62 | $2.45K |
| 01/14/26 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 2,813 | $10.00 | $28.13K |
| 01/14/26 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 5,893 | $15.75 | $92.81K |
| 01/14/26 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 2,678 | $35.15 | $94.13K |
| 01/14/26 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Sell | 13,112 | $45.20 | $592.61K |
| 01/13/26 | Sinha VikasChief Financial Officer | Sell | 16,755 | $42.70 | $715.44K |
| 01/13/26 | Woods KeithChief Operating Officer | Sell | 16,746 | $42.70 | $715.05K |
| 01/13/26 | Vaishnaw AkshayPresident of R&D, Director | Sell | 20,438 | $42.70 | $872.70K |
| 01/13/26 | Hallal DavidChief Executive Officer, Director | Sell | 57,450 | $42.70 | $2.45M |
| 12/16/25 | Peng KatieDirector | Sell | 726 | $43.88 | $31.85K |
| 12/16/25 | Peng KatieDirector | Sell | 280 | $44.63 | $12.50K |
| 12/12/25 | Akkaraju SrinivasDirector | Option Exercise | 1,064,804 | $7.35 | $7.83M |
| 12/11/25 | Invus Global Management, Llc10%+ Owner+ 2 joint filers | Option Exercise | 1,575,008 | $7.35 | $11.58M |
| 12/04/25 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 65,625 | $26.05 | $1.71M |
| 12/04/25 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 21,093 | $18.08 | $381.36K |
| 12/04/25 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 5,607 | $4.86 | $27.25K |
| 12/04/25 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 1,281 | $7.62 | $9.76K |
| 12/04/25 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 11,250 | $10.00 | $112.50K |
| 12/04/25 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 23,571 | $15.75 | $371.24K |
| 12/04/25 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Option Exercise | 8,035 | $35.15 | $282.43K |
| 12/04/25 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Sell | 136,462 | $45.21 | $6.17M |
| 10/08/25 | Hallal DavidChief Executive Officer, Director | Gift | 205,000 | - | - |
| 10/07/25 | Akkaraju SrinivasDirector | Buy | 12,796 | $39.31 | $503.01K |
| 10/07/25 | Akkaraju SrinivasDirector | Buy | 12,400 | $40.18 | $498.23K |
| 10/07/25 | Akkaraju SrinivasDirector | Buy | 4,403 | $40.97 | $180.39K |
| 10/06/25 | Akkaraju SrinivasDirector | Buy | 18,414 | $37.89 | $697.71K |
| 10/06/25 | Akkaraju SrinivasDirector | Buy | 80,863 | $38.68 | $3.13M |
| 10/06/25 | Akkaraju SrinivasDirector | Buy | 13,748 | $39.52 | $543.32K |
| 10/03/25 | Akkaraju SrinivasDirector | Buy | 11,011 | $35.61 | $392.10K |
| 10/03/25 | Akkaraju SrinivasDirector | Buy | 56,703 | $36.74 | $2.08M |
| 10/03/25 | Akkaraju SrinivasDirector | Buy | 319,700 | $37.42 | $11.96M |
| 09/22/25 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Sell | 3,353 | $30.67 | $102.85K |
| 09/16/25 | Peng KatieDirector | Sell | 930 | $32.48 | $30.20K |
| 09/16/25 | Peng KatieDirector | Sell | 76 | $33.20 | $2.52K |
| 09/16/25 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Sell | 3,178 | $33.52 | $106.53K |
| 08/18/25 | Parlavecchio CarynCHRO | Sell | 2,178 | $31.17 | $67.88K |
| 07/16/25 | Flier Jeffrey S.Director | Sell | 11,136 | $40.02 | $445.69K |
| 07/08/25 | Qatanani MoCHIEF SCIENTIFIC OFFICER | Sell | 24,066 | $34.44 | $828.90K |